DUPLET

DUal Positron Lifetime Emission Tomography

Started
December 1, 2022
Status
In Progress
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Abstract

In recent years, there is growing evidence that the combination of metabolic- and receptor-targeted positron emission tomography (PET) imaging can optimize treatment planning for metastatic cancer patients. However, the corresponding diagnostics, performing multiple PET/CT scans, are currently not common clinical practice because of costs and availability issues of the infrastructure. The DUPLET project aims to leverage particle physics technology, state-of-the-art clinical expertise and newest radiopharmaceutical developments to combine multiple diagnostic procedures into one single scan to make optimal treatment selection viable for daily clinical practice.

People

Collaborators

SDSC Team:
Lin Zhang
Benjamin Béjar Haro
Fernando Perez-Cruz

PI | Partners:

ETH Zurich, Center for Radiopharmaceutical Sciences:

  • Prof. Roger Schibli
  • Dr. Lars Gerchow

More info

ETH Zurich, Institute for Particle Physics and Astrophysics:

  • Dr. Carlos Vigo

More info

Kantonsspital Baden AG, Department of Nuclear Medicine:

  • PD Dr. Irene Burger

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University Hospital Zurich, Department of Nuclear Medicine:

  • PD Dr. Valerie Treyer

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description

Motivation

Recently, treatment of certain tumors (prostate, neuroendocrine) with radiotherapy by local internal direct irradiation has seen a wide and successful adoption. However, the diagnostics to forecast an effective treatment nowadays requires two separate PET/CT scans resulting in a higher radiation dose and costs of additional scans and/or mistreatments. The project aims to enable simultaneous dual tracer PET scans for the first time using existing clinical devices, by incorporating Positron Annihilation Spectroscopy (PAS) into the PET data processing pipeline.

Proposed Approach / Solution

In this project, SDSC contributes to the development of event selection algorithms to discriminate sources of coincidences by leveraging the isotope decay model; and advanced image reconstruction algorithms to further improve the quality of dual tracer scans. An overview of the data processing pipeline is outlined in Figure 1.

Figure 1: DUPLET data processing pipeline.

Impact

DUPLET is introducing a pioneering technology enabling the simultaneous integration of metabolic- and receptor-targeted PET scans. If successful, DUPLET holds the immediate potential to improve patient selection and deepen our understanding of various tumor responses to treatment.

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Annexe

Additional resources

Bibliography

  1. Hofman, M. S. et al. “[177Lu]Lu-PSMA-617 versus Cabazitaxel in Patients with Metastatic Castration-Resistant Prostate Cancer (TheraP): A Randomised, Open-Label, Phase 2 Trial.” The Lancet 397 (2021): 797–804.
  2. Rohith G. “VISION trial: 177Lu-PSMA-617 for progressive metastatic castration-resistant prostate cancer.” Indian J Urol. 37 (2021): 372-373
  3. Ferraro, D.A., et al. “Improved oncological outcome after radical prostatectomy in patients staged with 68Ga-PSMA-11 PET: a single-center retrospective cohort comparison.” Eur J Nucl Med Mol Imaging 48 (2021): 1219–1228
  4. Huang, S. C., et al. "An investigation of a double-tracer technique for positron computerized tomography." Journal of Nuclear Medicine 23.9 (1982): 816-822.
  5. Ding, Wenxiang, et al. "Machine learning-based noninvasive quantification of single-imaging session dual-tracer 18 F-FDG and 68 Ga-DOTATATE dynamic PET-CT in oncology." IEEE transactions on medical imaging 41.2 (2021): 347-359.

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